Hydrochloric Acid → 8-Amino-7-(2-fluoro-4-iodo-phenylamino)-6-methyl-2,3-dihydro-thiazolo[3,2-a]pyridin-5-one

Participants

Reaction Steps

Concentrated HCl (0.3 mL) and SnCl2.H2O (0.15 g, 0.671 mmol) were added to 7-(2-fluoro-4-iodo-phenylamino)-6-methyl-8-nitro-2,3-dihydro-thiazolo[3,2-a]pyridin-5-one (0.1 g, 0.22 mmol) in ethanol (3 mL). The resulting mixture was heated to reflux for 2 hours. The reaction was monitored by TLC (100% ethylacetate). The reaction mixture was cooled to room temperature, diluted with DCM, basified with saturated bicarbonate solution and filtered through celite. The filtrate was extracted with DCM. The organic layer was washed with brine solution, dried over Na2SO4 and concentrated to afford 0.09 g of the product (90% yield).

Provenance & Evidence