反应详情

Concentrated HCl (0.3 mL) and SnCl2.H2O (0.15 g, 0.671 mmol) were added to 7-(2-fluoro-4-iodo-phenylamino)-6-methyl-8-nitro-2,3-dihydro-thiazolo[3,2-a]pyridin-5-one (0.1 g, 0.22 mmol) in ethanol (3 mL). The resulting mixture was heated to reflux for 2 hours. The reaction was monitored by TLC (100% ethylacetate). The reaction mixture was cooled to room temperature, diluted with DCM, basified with saturated bicarbonate solution and filtered through celite. The filtrate was extracted with DCM. The organic layer was washed with brine solution, dried over Na2SO4 and concentrated to afford 0.09 g of the product (90% yield).

1. temperatureThe resulting mixture was heated
2. temperatureto reflux for 2 hours
3. filtrationfiltered through celite
4. extractionThe filtrate was extracted with DCM
5. washThe organic layer was washed with brine solution
6. dry with materialdried over Na2SO4
7. concentrationconcentrated