反应详情

8-Amino-7-(2-fluoro-4-iodo-phenylamino)-6-methyl-2,3-dihydro-thiazolo[3,2-a]pyridin-5-one (I-19f: 0.3 g, 0.719 mmol) in pyridine (3 mL) was reacted with 1-allyl-cyclopropane sulfonyl chloride (0.15 g, 0.863 mmol) to afford the crude product. Purification by column chromatography on silica gel (40% ethylacetate in hexane) afforded 0.21 g of the product (52% yield).

1. customto afford the crude product
2. customPurification by column chromatography on silica gel (40% ethylacetate in hexane)