1-(Prop-2-en-1-yl)cyclopropane-1-sulfonyl chloride → 1-Allyl-cyclopropanesulfonic acid [7-(2-fluoro-4-iodo-phenylamino)-6-methyl-5-oxo-2,3-dihydro-5H-thiazolo[3,2-a]pyridin-8-yl]-amide

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Reaction Steps

8-Amino-7-(2-fluoro-4-iodo-phenylamino)-6-methyl-2,3-dihydro-thiazolo[3,2-a]pyridin-5-one (I-19f: 0.3 g, 0.719 mmol) in pyridine (3 mL) was reacted with 1-allyl-cyclopropane sulfonyl chloride (0.15 g, 0.863 mmol) to afford the crude product. Purification by column chromatography on silica gel (40% ethylacetate in hexane) afforded 0.21 g of the product (52% yield).

Provenance & Evidence