HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl Acetate → Potassium 3-(benzyloxy)cyclobutane-1-sulfonate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Potassium thiocyanate | HCID 516872 | — |
| Reactant | Butyl 3-(benzyloxy)cyclobutane-1-sulfonate | HCID 58380564 | — |
| Solvent | Hexane | HCID 8058 | — |
| Solvent | Water 1,2-dimethoxyethane | HCID 18180031 | — |
| Product | Potassium 3-(benzyloxy)cyclobutane-1-sulfonate | HCID 86656336 | 70% |
Reaction Steps
KSCN (68 mg, 0.66 mmol) and butyl 3-(benzyloxy)cyclobutane-1-sulfonate (0.18 g, 0.604 mmol) in DME-water mixture (1:1 ratio, 4 mL) were heated at 85° C. overnight. The reaction was monitored by TLC (50% ethyl acetate in hexane). The reaction mass was concentrated under reduced pressure and the crude residue obtained was washed with ether to afford 0.11 g of the product (70% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08466289B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-0b927242a0634ce6a0441bcdf72315dc |
| Source note | uspto-grants-2013_06 |