反应详情

KSCN (68 mg, 0.66 mmol) and butyl 3-(benzyloxy)cyclobutane-1-sulfonate (0.18 g, 0.604 mmol) in DME-water mixture (1:1 ratio, 4 mL) were heated at 85° C. overnight. The reaction was monitored by TLC (50% ethyl acetate in hexane). The reaction mass was concentrated under reduced pressure and the crude residue obtained was washed with ether to afford 0.11 g of the product (70% yield).

1. concentrationThe reaction mass was concentrated under reduced pressure
2. customthe crude residue obtained
3. washwas washed with ether