反应详情

Trifluoro-methanesulfonic acid 8-nitro-5-oxo-2,3-dihydro-5H-thiazolo[3,2-a]pyridin-7-yl ester (0.6 g, 1.7 mmol) was reacted with 2-fluoro-4-iodo-phenylamine (0.45 g, 1.9 mmol), Pd(OAc)2 (38 mg, 0.17 mmol), BINAP (0.1 g, 0.17 mmol) and cesium carbonate (0.84 g, 2.6 mmol) in toluene (20 mL) at reflux for 3 hours to afford the crude product. Purification by column chromatography on silica gel (30% ethylacetate in hexane) afforded 90 mg of the product (12% yield).

1. temperatureat reflux for 3 hours
2. customto afford the crude product
3. customPurification by column chromatography on silica gel (30% ethylacetate in hexane)