Hydrochloric Acid → 1-(3,5-Difluoropyridin-2-yl)piperazine

HRID 125945Notes

Reaction equation

HRID 125945 reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][CH2:10][N:11]([c:14]2[n:15][cH:16][c:17]([F:21])[cH:18][c:19]2[F:20])[CH2:12][CH2:13]1)([CH3:5])([CH3:6])[CH3:7].[ClH:22].[O:23]1[CH2:24][CH2:25][O:26][CH2:27][CH2:28]1>>[NH:8]1[CH2:9][CH2:10][N:11]([c:14]2[n:15][cH:16][c:17]([F:21])[cH:18][c:19]2[F:20])[CH2:12][CH2:13]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 674014754-(3,5-Difluoro-pyridin-2-yl)-piperazine-1-carboxylic acid tert-butyl ester

Product 1

HCID 451164141-(3,5-Difluoropyridin-2-yl)piperazine

Sources & evidence

ORD record
ord-eacc9d4fd8b9435d88dd4e1f336e2906
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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