HuagongsheHuagongshe Chemistry Print Report · For research reference only
Iodine → 4-hydroxy-3-methoxy-2-nitrobenzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Iodine | HCID 807 | — |
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | Benzaldehyde, 4-hydroxy-3-methoxy-2-nitro- | HCID 96959 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-hydroxy-3-methoxy-2-nitrobenzonitrile | HCID 7059265 | — |
Reaction Steps
4-Hydroxy-3-methoxy-2-nitrobenzaldehyde (200 g, 1.01 mol) was dissolved in THF (2.5 L) and then ammonium hydroxide (2.5 L) was added followed by iodine (464 g, 1.8 mol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08466283B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-a638210d2e6c4c1296028b718b48653d |
| Source note | uspto-grants-2013_06 |