1-Bromopentane → 4-methoxy-1-{[5-(trifluoromethyl)-2-furyl]methyl}-1H-indole-2,3-dione

HRID 1259614Notes

Reaction equation

HRID 1259614 reaction equation
BrC1C=CC=C2C=1C=CN2.[CH3:11][O:12][C:13]1[CH:21]=[CH:20][CH:19]=[C:18]2[C:14]=1[C:15](=[O:23])[C:16](=[O:22])[NH:17]2.BrCCCCC.Br[CH2:31][C:32]1[O:33][C:34]([C:37]([F:40])([F:39])[F:38])=[CH:35][CH:36]=1>>[CH3:11][O:12][C:13]1[CH:21]=[CH:20][CH:19]=[C:18]2[C:14]=1[C:15](=[O:23])[C:16](=[O:22])[N:17]2[CH2:31][C:32]1[O:33][C:34]([C:37]([F:40])([F:39])[F:38])=[CH:35][CH:36]=1

Participants

5

Reactant 4

HCID 80571-BromopentaneHCID 6764944-BromoindoleHCID 27946052-(Bromomethyl)-5-(trifluoromethyl)furanHCID 113788194-methoxy-2,3-dihydro-1H-indole-2,3-dione

Product 1

HCID 666426954-methoxy-1-{[5-(trifluoromethyl)-2-furyl]methyl}-1H-indole-2,3-dione

Procedure

Following the procedure as described in PREPARATION 1A, and making non-critical variations to replace 4-bromoindole with 4-methoxy-1H-indole-2,3-dione, and 1-bromopentane with 2-(bromomethyl)-5-(trifluoromethyl)furan, the title compound was obtained (26%): MS (ES+) m/z 348.2 (M+23).

Sources & evidence

ORD record
ord-15fba71e55c046ff8daa1edaef6e8460
Source dataset
uspto-grants-2013_06
Patent number
US08466188B2

Reaction notes

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