1-Hydroxybenzotriazole → HCID 178522633, compound

HRID 1259848Notes

Reaction equation

HRID 1259848 reaction equation
[OH:1][C:2]1[CH:11]=[C:10]([C:12]([OH:14])=O)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.CN(C(ON1[N:31]=[N:30][C:25]2[CH:26]=[CH:27][CH:28]=[CH:29]C1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.C1C=CC2N([OH:48])N=NC=2C=1.C[N:50]([C:52]([O:56]N1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.C1C=NC2N(O)N=NC=2C=1>>[O:48]1[CH:29]=[CH:28][CH:27]=[C:26]1[C:25]1[O:56][C:52]([NH:50][C:12]([C:10]2[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[N:3]=[C:2]([OH:1])[CH:11]=2)=[O:14])=[N:31][N:30]=1

Participants

6

Reactant 5

HCID 757711-HydroxybenzotriazoleHCID 181649HOAtHCID 2733084Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 178524625HCID 178524625, compound

Product 1

HCID 178522633HCID 178522633, compound

Procedure

The title compound was synthesized according to the synthesis method of a compound Ia-46 described later using 2-hydroxy-4-quinolinecarboxylic acid, commercially available amine, HBTU, and HOBt instead of 2-(4-fluorophenyl)-4-quinolinecarboxylic acid, HATU, and HOAt.

Workup

  1. customaccording to the synthesis method of a compound Ia-46

Sources & evidence

ORD record
ord-98256e3ef7264c76951ee9f7f832af0e
Source dataset
uspto-grants-2013_06
Patent number
US08466290B2

Reaction notes

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