1-Hydroxybenzotriazole → HCID 67205075, compound

HRID 1259849Notes

Reaction equation

HRID 1259849 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[C:10]1[CH:19]=[C:18]([C:20](O)=[O:21])[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[N:11]=1)([O-:3])=[O:2].CN(C(ON1[N:39]=[N:38][C:33]2[CH:34]=[CH:35][CH:36]=[CH:37]C1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.C1C=CC2N([OH:56])N=NC=2C=1.C[N:58]([C:60]([O:64]N1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.C1C=NC2N(O)N=NC=2C=1>>[O:56]1[CH:37]=[CH:36][CH:35]=[C:34]1[C:33]1[O:64][C:60]([NH:58][C:20]([C:18]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[N:11]=[C:10]([C:5]3[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=3[N+:1]([O-:3])=[O:2])[CH:19]=2)=[O:21])=[N:39][N:38]=1

Participants

6

Reactant 5

HCID 757711-HydroxybenzotriazoleHCID 181649HOAtHCID 2733084Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 15814118HCID 15814118, compound

Product 1

HCID 67205075HCID 67205075, compound

Procedure

The title compound was synthesized according to the synthesis method of a compound Ia-46 described later using 2-(2-nitrophenyl)-4-quinolinecarboxylic acid described in Reference Example 7, HBTU, and HOBt instead of 2-(4-fluorophenyl)-4-quinolinecarboxylic acid, HATU, and HOAt, respectively.

Workup

  1. customaccording to the synthesis method of a compound Ia-46

Sources & evidence

ORD record
ord-abe88a4796274fc58fae3752ca0ade00
Source dataset
uspto-grants-2013_06
Patent number
US08466290B2

Reaction notes

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