1-Hydroxybenzotriazole → HCID 67204213, compound

HRID 1259851Notes

Reaction equation

HRID 1259851 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[CH:6]=[C:5]2[C:18](O)=[O:19].CN(C(ON1[N:37]=[N:36][C:31]2[CH:32]=[CH:33][CH:34]=[CH:35]C1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.C1C=CC2N([OH:54])N=NC=2C=1.C[N:56]([C:58]([O:62]N1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.C1C=NC2N(O)N=NC=2C=1>>[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[CH:6]=[C:5]2[C:18]([NH:56][C:58]1[O:62][C:31]([C:32]2[O:54][CH:35]=[CH:34][CH:33]=2)=[N:36][N:37]=1)=[O:19]

Participants

6

Reactant 5

HCID 757711-HydroxybenzotriazoleHCID 181649HOAtHCID 763956HCID 763956, compoundHCID 2733084Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)

Product 1

HCID 67204213HCID 67204213, compound

Procedure

The title compound was synthesized according to the synthesis method of the compound Ia-46 using 6-fluoro-2-phenyl-4-quinolinecarboxylic acid described in Reference Example 17, HBTU, and HOBt instead of 2-(4-fluorophenyl)-4-quinolinecarboxylic acid, HATU, and HOAt, respectively.

Workup

  1. customaccording to the synthesis method of the compound

Sources & evidence

ORD record
ord-bccc1231043b40b19d08d05ebad449d2
Source dataset
uspto-grants-2013_06
Patent number
US08466290B2

Reaction notes

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