Sodium Chloride → 2-Bromoquinoline-4-carboxylic acid

HRID 1259859Notes

Reaction equation

HRID 1259859 reaction equation
P(Br)(Br)([Br:3])=O.O[C:7]1[CH:16]=[C:15]([C:17]([OH:19])=[O:18])[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[N:8]=1.[Cl-].[Na+]>>[Br:3][C:7]1[CH:16]=[C:15]([C:17]([OH:19])=[O:18])[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[N:8]=1

Participants

4

Reactant 3

HCID 5234Sodium ChlorideHCID 24613Phosphorus oxybromideHCID 178524625HCID 178524625, compound

Product 1

HCID 155506972-Bromoquinoline-4-carboxylic acid

Conditions

Temperature
90 °C

Procedure

Phosphorus oxybromide (5.00 g, 17.4 mmol) was added to commercially available 2-hydroxy-4-quinolinecarboxylic acid (1.00 g, 5.29 mmol), and the mixture was heated with stirring at 90° C. for 4 hours. The reaction solution was added to ice water. To the mixture, sodium chloride was added, and the deposited crystal was collected by filtration, washed with water, and dried to obtain the title compound.

Workup

  1. temperaturethe mixture was heated
  2. filtrationthe deposited crystal was collected by filtration
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-5b4fb6e6560d4022b3e467e8616423ea
Source dataset
uspto-grants-2013_06
Patent number
US08466290B2

Reaction notes

Loading…