Methanol → HCID 67204266, compound

HRID 1259864Notes

Reaction equation

HRID 1259864 reaction equation
CO.C([O:10][C:11]([C:13]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[N:16]=[C:15]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=2[O:29][C:30](=[O:32])[CH3:31])[CH:14]=1)=[O:12])C1C=CC=CC=1.[H][H]>O.[C].[Pd]>[C:30]([O:29][C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][C:23]=1[C:15]1[CH:14]=[C:13]([C:11]([OH:12])=[O:10])[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[N:16]=1)(=[O:32])[CH3:31]

Participants

6

Reactant 3

HCID 887MethanolHCID 67204263HCID 67204263, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 67204266HCID 67204266, compoundYield 85%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 962WaterSolvent

Procedure

A suspension of 50% hydrated 10% palladium-carbon (180 mg) in water (1 mL) was added to a methanol (10 mL) solution of 2-(2-acetoxyphenyl)-4-quinolinecarboxylic acid benzyl ester (940 mg, 2.34 mmol) obtained above, and the mixture was stirred for 7 hours in a hydrogen atmosphere. The catalyst was filtered off through celite, and then, the solvent was distilled off to obtain the title compound (610 mg, 1.99 mmol).

Workup

  1. customobtained above, and the mixture
  2. filtrationThe catalyst was filtered off through celite
  3. distillationthe solvent was distilled off

Sources & evidence

ORD record
ord-32acab3cc7dd49e592b6444a60d803fd
Source dataset
uspto-grants-2013_06
Patent number
US08466290B2

Reaction notes

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