Hydrogen chloride-ethyl acetate → HCID 67321273, compound

HRID 1260103Notes

Reaction equation

HRID 1260103 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7]1[N:11]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[CH3:18])[N:10]=[N:9][C:8]=1[C:19]([N:21]([CH2:43][CH:44]([CH3:46])[CH3:45])[C@H:22]1[CH2:27][C@@H:26]([C:28]([N:30]2[CH2:35][CH2:34][O:33][CH2:32][CH2:31]2)=[O:29])[CH2:25][N:24](C(OC(C)(C)C)=O)[CH2:23]1)=[O:20].C(OCC)(=O)C.[ClH:53]>C(OCC)(=O)C>[ClH:53].[CH3:1][O:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7]1[N:11]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[CH3:18])[N:10]=[N:9][C:8]=1[C:19]([N:21]([CH2:43][CH:44]([CH3:46])[CH3:45])[C@H:22]1[CH2:27][C@@H:26]([C:28]([N:30]2[CH2:35][CH2:34][O:33][CH2:32][CH2:31]2)=[O:29])[CH2:25][NH:24][CH2:23]1)=[O:20]

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 58355761HCID 58355761, compound

Product 1

HCID 67321273HCID 67321273, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

tert-Butyl (3S,5R)-3-[{[5-(4-methoxybutyl)-1-(2-methylphenyl)-1H-1,2,3-triazol-4-yl]carbonyl}(2-methylpropyl)amino]-5-(morpholin-4-ylcarbonyl)piperidine-1-carboxylate (255 mg) was dissolved in ethyl acetate (0.5 ml), 4N hydrogen chloride-ethyl acetate solution (0.5 ml) was added, and the mixture was stirred at room temperature for 1 hr. The solvent was evaporated under reduced pressure, and the residue was dried under reduced pressure to give the object product (220 mg).

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. customthe residue was dried under reduced pressure

Sources & evidence

ORD record
ord-1d99e705174c4522871ccca6e7b4ca8d
Source dataset
uspto-grants-2013_06
Patent number
US08466282B2

Reaction notes

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