Hydrogen Sulfide → HCID 58283708, compound

HRID 1260142Notes

Reaction equation

HRID 1260142 reaction equation
[SH2:1].[NH2:2][C:3](=[C:8]([C:11]#[N:12])[C:9]#[N:10])[C:4]([CH3:7])([CH3:6])[CH3:5].C(N(CC)CC)C.N1C=CC=CC=1>>[NH2:2]/[C:3](/[C:4]([CH3:7])([CH3:5])[CH3:6])=[C:8](\[C:9]#[N:10])/[C:11](=[S:1])[NH2:12]

Participants

5

Reactant 4

HCID 402Hydrogen SulfideHCID 1049PyridineHCID 8471TriethylamineHCID 102360162-(1-Amino-2,2-dimethylpropylidene)propanedinitrile

Product 1

HCID 58283708HCID 58283708, compound

Procedure

With cooling, 1.52 g (4.50 mmol) of hydrogen sulphide are introduced as a gas into a mixture of 1.6 g (1.40 mmol) of (1-amino-2,2-dimethylpropylidene)propanedinitrile, 1.41 g (1.40 mmol) of triethylamine and 2.21 g (2.80 mmol) of pyridine. For 1 h, nitrogen is then passed through the reaction mixture, and the reaction mixture is then added to ice-water and extracted with dichloromethane. The combined organic phases are dried over MgSO4 and freed from the solvent under reduced pressure.

Workup

  1. temperatureWith cooling
  2. extractionextracted with dichloromethane
  3. dry with materialThe combined organic phases are dried over MgSO4

Sources & evidence

ORD record
ord-48b7b313473048cc926e4997f3fb8bff
Source dataset
uspto-grants-2013_06
Patent number
US08470739B2

Reaction notes

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