Citric Acid → KMUP-1 Citric acid

HRID 1260165Notes

Reaction equation

HRID 1260165 reaction equation
[CH3:1][N:2]1[C:8](=[O:9])[N:7]([CH3:10])[C:5](=[O:6])[C:4]2[N:11]([CH2:14][CH2:15][N:16]3[CH2:21][CH2:20][N:19]([C:22]4[C:27]([Cl:28])=[CH:26][CH:25]=[CH:24][CH:23]=4)[CH2:18][CH2:17]3)[CH:12]=[N:13][C:3]1=2.CO.[C:31]([OH:43])(=[O:42])[CH2:32][C:33]([CH2:38][C:39]([OH:41])=[O:40])([C:35]([OH:37])=[O:36])[OH:34]>C(O)C>[CH3:1][N:2]1[C:8](=[O:9])[N:7]([CH3:10])[C:5](=[O:6])[C:4]2[N:11]([CH2:14][CH2:15][N:16]3[CH2:21][CH2:20][N:19]([C:22]4[C:27]([Cl:28])=[CH:26][CH:25]=[CH:24][CH:23]=4)[CH2:18][CH2:17]3)[CH:12]=[N:13][C:3]1=2.[C:31]([OH:43])(=[O:42])[CH2:32][C:33]([CH2:38][C:39]([OH:41])=[O:40])([C:35]([OH:37])=[O:36])[OH:34]

Participants

5

Reactant 3

HCID 311Citric AcidHCID 887MethanolHCID 10453764Kmup 1

Product 1

HCID 49783485KMUP-1 Citric acidYield 88.9%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

KMUP-1 (8.0 g) is dissolved in a mixture of ethanol (10 mL) and citric acid (4 g) and reacted at 50° C. for 20 min, the methanol is added thereinto under room temperature and the solution is incubated over night for crystallization and filtrated to obtain KMUP-1-Citric acid salt (10.5 g).

Workup

  1. customreacted at 50° C. for 20 min
  2. customunder room temperature and the solution is incubated over night for crystallization
  3. filtrationfiltrated

Sources & evidence

ORD record
ord-58696b869e9146ebb174ff76c9d355fb
Source dataset
uspto-grants-2013_06
Patent number
US08470805B2

Reaction notes

Loading…