Ethanol → KMUP-1 Nicotinic acid

HRID 1260166Notes

Reaction equation

HRID 1260166 reaction equation
[CH3:1][N:2]1[C:8](=[O:9])[N:7]([CH3:10])[C:5](=[O:6])[C:4]2[N:11]([CH2:14][CH2:15][N:16]3[CH2:21][CH2:20][N:19]([C:22]4[C:27]([Cl:28])=[CH:26][CH:25]=[CH:24][CH:23]=4)[CH2:18][CH2:17]3)[CH:12]=[N:13][C:3]1=2.C[OH:30].[CH2:31]([OH:33])[CH3:32]>C(O)(=O)C1C=CC=NC=1>[CH3:1][N:2]1[C:8](=[O:9])[N:7]([CH3:10])[C:5](=[O:6])[C:4]2[N:11]([CH2:14][CH2:15][N:16]3[CH2:21][CH2:20][N:19]([C:22]4[C:27]([Cl:28])=[CH:26][CH:25]=[CH:24][CH:23]=4)[CH2:18][CH2:17]3)[CH:12]=[N:13][C:3]1=2.[C:31]([OH:30])(=[O:33])[C:32]1[CH:5]=[CH:4][CH:3]=[N:2][CH:1]=1

Participants

5

Reactant 3

HCID 702EthanolHCID 887MethanolHCID 10453764Kmup 1

Product 1

HCID 51039835KMUP-1 Nicotinic acid

Reagents, catalysts & solvents 1

HCID 938Nicotinic AcidSolvent

Procedure

KMUP-1 (8.0 g) is dissolved in a mixture of ethanol (10 mL) and nicotinic acid (2.4 g) and reacted at 50° C. for 20 min, the methanol is added thereinto under room temperature and the solution is incubated over night for crystallization and filtrated to obtain KMUP-1-Nicotinic acid salt (8.3 g).

Workup

  1. customreacted at 50° C. for 20 min
  2. customunder room temperature and the solution is incubated over night for crystallization
  3. filtrationfiltrated

Sources & evidence

ORD record
ord-72f38d681114404db802a736be8234bd
Source dataset
uspto-grants-2013_06
Patent number
US08470805B2

Reaction notes

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