huagongshe.com
HRID1260169

反应详情

EQUATION

反应方程式

HRID 1260169 的结构方程式

REACTANTS

反应物

3
结构：CO
HCID887

Methanol

CH4O

结构：Cn1c(=O)c2c(ncn2CCN2CCN(c3ccccc3Cl)CC2)n(C)c1=O
HCID10453764

KMUP-1

C19H23ClN6O2

结构：CC(C)[C@H]1CC[C@H](C(=O)N[C@H](Cc2ccccc2)C(=O)O)CC1
HCID178448095

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)[C@H]1CC[C@H](C(=O)N[C@H](Cc2ccccc2)C(=O)O)CC1.Cn1c(=O)c2c(ncn2CCN2CCN(c3ccccc3Cl)CC2)n(C)c1=O
HCID178448096

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

2
结构：CCO
溶剂HCID702

Ethanol

C2H6O

2 次

结构：O
溶剂HCID962

Water

H2O

PROCEDURE

实验过程

KMUP-1 (8.0 g) is dissolved in a mixture of ethanol (100 mL) and water (30 mL), to which nateglinide (9.1 g) dissolved in ethyl alcohol (150 mL) is added, and the mixture is reacted at 50° C. for 20 mins. After cooling the mixture, the white precipitate is obtained, to which the methanol is added under room temperature and being incubated over night for re-crystallization. After filtering, KMUP-1-nateglinide complex (15.3 g) is obtained.

WORKUP

后处理

  1. additionis added
  2. customthe mixture is reacted at 50° C. for 20 mins
  3. temperatureAfter cooling the mixture
  4. additionis added under room temperature
  5. custombeing incubated over night for re-crystallization
  6. filtrationAfter filtering
  7. customKMUP-1-nateglinide complex (15.3 g) is obtained