Piperidin-4-ol → HCID 54591442, compound

HRID 1260195Notes

Reaction equation

HRID 1260195 reaction equation
Br[C:2]1[CH:3]=[C:4]([CH:30]=[CH:31][CH:32]=1)[CH2:5][N:6]1[C:10]([CH3:11])=[CH:9][C:8]([C:12]2[O:16][N:15]=[C:14]([C:17]3[CH:22]=[CH:21][C:20]([C:23]4([C:26]([F:29])([F:28])[F:27])[CH2:25][CH2:24]4)=[CH:19][CH:18]=3)[N:13]=2)=[N:7]1.[OH:33][CH:34]1[CH2:39][CH2:38][NH:37][CH2:36][CH2:35]1>>[CH3:11][C:10]1[N:6]([CH2:5][C:4]2[CH:3]=[C:2]([N:37]3[CH2:38][CH2:39][CH:34]([OH:33])[CH2:35][CH2:36]3)[CH:32]=[CH:31][CH:30]=2)[N:7]=[C:8]([C:12]2[O:16][N:15]=[C:14]([C:17]3[CH:22]=[CH:21][C:20]([C:23]4([C:26]([F:29])([F:28])[F:27])[CH2:25][CH2:24]4)=[CH:19][CH:18]=3)[N:13]=2)[CH:9]=1

Participants

3

Reactant 2

HCID 79341Piperidin-4-olHCID 58072162HCID 58072162, compound

Product 1

HCID 54591442HCID 54591442, compound

Procedure

Analogously to the process described in Example 3, 125 mg (0.248 mmol) of the compound from Example 2A and 50 mg (0.497 mmol) of 4-hydroxypiperidine were used to obtain 20 mg (16% of theory) of the title compound. The first component step of the process was effected here at a reaction temperature of 130° C. The preparative HPLC purification was performed by method 11

Sources & evidence

ORD record
ord-8fed11baf93c407d92bf4a3aea7627ee
Source dataset
uspto-grants-2013_06
Patent number
US08470811B2

Reaction notes

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