Hydrochloric Acid → HCID 15451836, compound

HRID 1260341Notes

Reaction equation

HRID 1260341 reaction equation
[F:1][C:2]1([F:21])[O:6][C:5]2[CH:7]=[CH:8][C:9]([N:11]3[CH2:15][C:14](=[CH2:16])[S:13]/[C:12]/3=[N:17]\C(=O)C)=[CH:10][C:4]=2[O:3]1.Cl>C(O)C.O>[F:21][C:2]1([F:1])[O:6][C:5]2[CH:7]=[CH:8][C:9]([N:11]3[CH:15]=[C:14]([CH3:16])[S:13][C:12]3=[NH:17])=[CH:10][C:4]=2[O:3]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178429856HCID 178429856, compound

Product 1

HCID 15451836HCID 15451836, compound

Reagents, catalysts & solvents 1

HCID 19096565Water ethanolSolvent

Procedure

A mixture of Example 5 (1.8 g, 5.76 mmol) and hydrochloric acid (38%, 4.76 mL) in 40 mL of ethanol-water (1:1) was refluxed for 15 hours. Then the solvent was removed under reduced pressure, and the residue was carried on to the next step. 1H NMR (CD3OD) δ ppm 2.28 (3H), 7.15 (1H), 7.40-7.65 (3H); MS (ESI) 271(M+H).

Workup

  1. customThen the solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-c55691560941400198edbbfd70e36241
Source dataset
uspto-grants-2013_06
Patent number
US08470813B2

Reaction notes

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