Hydrochloric Acid → (8aS)-2-[(1S,2R)-2-Phenylcyclopropyl]tetrahydroimidazo[1,5-a]pyrazine-1,3(2H,5H)-dione HCl salt

HRID 1260467노트

반응식

HRID 1260467 반응식
[ClH:1].O1CCOCC1.[C:8]1([C@H:14]2[CH2:16][C@@H:15]2[NH:17][C:18]([N:20]2[CH2:25][CH2:24][N:23](C(OC(C)(C)C)=O)[CH2:22][C@H:21]2[C:33]([O:35]C)=O)=[O:19])[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>>[ClH:1].[C:8]1([C@H:14]2[CH2:16][C@@H:15]2[N:17]2[C:33](=[O:35])[C@@H:21]3[CH2:22][NH:23][CH2:24][CH2:25][N:20]3[C:18]2=[O:19])[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 86656057HCID 86656057, 화합물

생성물 1

HCID 67300061(8aS)-2-[(1S,2R)-2-Phenylcyclopropyl]tetrahydroimidazo[1,5-a]pyrazine-1,3(2H,5H)-dione HCl salt

실험 절차

4N HCl solution in dioxane (44 eq.) was added at RT to D1. The resulting 0.1 M solution obtained was stirred for 1 h at RT, then the solvent was removed under reduced pressure. The residue was co-evaporated with toluene (×3) and it was used as such in next step without further purification. MS (ES+) C15H17N3O2 requires 271, found: 272 (M+H)+.

출처 및 근거

ORD 기록
ord-d3ba36f2a8554105bb43127f58a72e66
출처 데이터셋
uspto-grants-2013_06
특허 번호
US08470823B2

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