HRID1260479

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID81326

1-Methylcyclopropanecarboxylic acid

C5H8O2

HCID81531

Diisopropylethylamine

C8H19N

结构：CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F

HCID2733207

O-(Benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate

C11H16BF4N5O

结构：O=C(Nc1cccc(Cl)c1Cl)N1CCN2C(=O)N([C@H]3C[C@@H]3c3ccccc3)C(=O)[C@@H]2C1

HCID56676510

未命名化合物

结构：Cl.O=C1[C@@H]2CNCCN2C(=O)N1[C@H]1C[C@@H]1c1ccccc1

HCID67300061

未命名化合物

PRODUCTS

生成物

结构：CC1(C(=O)N2CCN3C(=O)N([C@H]4C[C@@H]4c4ccccc4)C(=O)[C@@H]3C2)CC1

HCID67300208

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

To a 0.2 M solution of Example 4, D2 (1 eq) in DMF were added 1-methylcyclopropanecarboxylic acid (1.1 eq), DIPEA (2.5 eq) and TBTU (1.5 eq). The reaction mixture was stirred at RT for 12 h. The crude product was purified by preparative RP-HPLC using H2O (0.1% TFA) and MeCN (0.1% TFA) as eluents, affording the title compound. 1H NMR (300 MHz, DMSO-d6, 300K) δ: 7.27-7.09 (5H, m), 4.42-4.32 (1H, m), 4.19 (1H, d, J=9.3 Hz), 4.05-3.95 (1H, m), 3.91-3.82 (1H, m), 2.97-2.81 (3H, m), 2.65-2.57 (1H, m), 2.36-2.26 (1H, m), 1.49-1.40 (1H, m), 1.39-1.30 (1H, m), 1.18 (3H, s), 0.83-0.76 (2H, m), 0.54-0.48 (2H, m). MS (ES) C20H23N3O3 requires: 353, found: 354 (M+H)+.

WORKUP

后处理

customThe crude product was purified by preparative RP-HPLC