2-Chloropyridine-3-sulfonyl chloride → HCID 56602661, compound

HRID 1260484Notes

Reaction equation

HRID 1260484 reaction equation
[OH:1][CH:2]1[CH2:23][NH:22][CH2:21][CH2:20][C:3]21[C:7](=[O:8])[N:6]([C:9]1[CH:14]=[CH:13][C:12]([O:15][C:16]([F:19])([F:18])[F:17])=[CH:11][CH:10]=1)[CH2:5][CH2:4]2.[Cl:24][C:25]1[C:30]([S:31](Cl)(=[O:33])=[O:32])=[CH:29][CH:28]=[CH:27][N:26]=1>>[Cl:24][C:25]1[C:30]([S:31]([N:22]2[CH2:21][CH2:20][C:3]3([C:7](=[O:8])[N:6]([C:9]4[CH:14]=[CH:13][C:12]([O:15][C:16]([F:19])([F:17])[F:18])=[CH:11][CH:10]=4)[CH2:5][CH2:4]3)[CH:2]([OH:1])[CH2:23]2)(=[O:33])=[O:32])=[CH:29][CH:28]=[CH:27][N:26]=1

Participants

3

Reactant 2

HCID 102199682-Chloropyridine-3-sulfonyl chlorideHCID 58056623HCID 58056623, compound

Product 1

HCID 56602661HCID 56602661, compound

Procedure

The title compound was prepared in analogy to example 2 step B from a mixture of (5SR,6RS)-6-hydroxy-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one (described in example 2 step A) and 2-chloro-pyridine-3-sulfonyl chloride. Colourless solid. MS (ESI): 506.0 (MH+)

Sources & evidence

ORD record
ord-db3abe7777a1455692e74712387aefb0
Source dataset
uspto-grants-2013_06
Patent number
US08470843B2

Reaction notes

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