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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1260484Generated: October 30, 2026

2-Chloropyridine-3-sulfonyl chloride → (5RS,6RS)-8-(2-Chloro-pyridine-3-sulfonyl)-6-hydroxy-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one

https://huagongshe.com/reaction/1260484

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Chloropyridine-3-sulfonyl chlorideHCID 10219968—
ReactantHCID 58056623HCID 58056623—
Product(5RS,6RS)-8-(2-Chloro-pyridine-3-sulfonyl)-6-hydroxy-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-oneHCID 56602661—

Reaction Steps

The title compound was prepared in analogy to example 2 step B from a mixture of (5SR,6RS)-6-hydroxy-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one (described in example 2 step A) and 2-chloro-pyridine-3-sulfonyl chloride. Colourless solid. MS (ESI): 506.0 (MH+)

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08470843B2
Source datasetuspto-grants-2013_06
ORD IDord-db3abe7777a1455692e74712387aefb0
Source noteuspto-grants-2013_06