2-(Trifluoromethoxy)benzene-1-sulfonyl chloride → (5RS,6RS)-6-Hydroxy-8-(2-trifluoromethoxy-benzenesulfonyl)-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one

HRID 1260485Notes

Reaction equation

HRID 1260485 reaction equation
[OH:1][CH:2]1[CH2:23][NH:22][CH2:21][CH2:20][C:3]21[C:7](=[O:8])[N:6]([C:9]1[CH:14]=[CH:13][C:12]([O:15][C:16]([F:19])([F:18])[F:17])=[CH:11][CH:10]=1)[CH2:5][CH2:4]2.[F:24][C:25]([F:38])([F:37])[O:26][C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=1[S:33](Cl)(=[O:35])=[O:34]>>[OH:1][CH:2]1[CH2:23][N:22]([S:33]([C:28]2[CH:29]=[CH:30][CH:31]=[CH:32][C:27]=2[O:26][C:25]([F:24])([F:37])[F:38])(=[O:35])=[O:34])[CH2:21][CH2:20][C:3]21[C:7](=[O:8])[N:6]([C:9]1[CH:14]=[CH:13][C:12]([O:15][C:16]([F:19])([F:17])[F:18])=[CH:11][CH:10]=1)[CH2:5][CH2:4]2

Participants

3

Reactant 2

HCID 27772152-(Trifluoromethoxy)benzene-1-sulfonyl chlorideHCID 58056623HCID 58056623, compound

Product 1

HCID 56602662(5RS,6RS)-6-Hydroxy-8-(2-trifluoromethoxy-benzenesulfonyl)-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one

Procedure

The title compound was prepared in analogy to example 2 step B from a mixture of (5SR,6RS)-6-hydroxy-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one (described in example 2 step A) and 2-trifluoromethoxy-benzenesulfonyl chloride. Colourless solid. MS (ESI): 555.2 (MH+)

Sources & evidence

ORD record
ord-005c59c1efb4430cab297c332fee0adf
Source dataset
uspto-grants-2013_06
Patent number
US08470843B2

Reaction notes

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