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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1260485Generated: November 1, 2026

2-(Trifluoromethoxy)benzene-1-sulfonyl chloride → (5RS,6RS)-6-Hydroxy-8-(2-trifluoromethoxy-benzenesulfonyl)-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one

https://huagongshe.com/reaction/1260485

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(Trifluoromethoxy)benzene-1-sulfonyl chlorideHCID 2777215—
Reactant6-Hydroxy-2-(4-(trifluoromethoxy)phenyl)-2,8-diazaspiro[4.5]decan-1-oneHCID 58056623—
Product(5RS,6RS)-6-Hydroxy-8-(2-trifluoromethoxy-benzenesulfonyl)-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-oneHCID 56602662—

Reaction Steps

The title compound was prepared in analogy to example 2 step B from a mixture of (5SR,6RS)-6-hydroxy-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one (described in example 2 step A) and 2-trifluoromethoxy-benzenesulfonyl chloride. Colourless solid. MS (ESI): 555.2 (MH+)

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08470843B2
Source datasetuspto-grants-2013_06
ORD IDord-005c59c1efb4430cab297c332fee0adf
Source noteuspto-grants-2013_06