(5 SR,6RS)-8-benzyl-6-hydroxy-2-[4-((rac)-2,2,2-trifluoro-1-methyl-ethoxy)-phenyl]-2,8-diaza-spiro[4.5]decan-1-one → HCID 58056627, compound

HRID 1260493Notes

Reaction equation

HRID 1260493 reaction equation
C([N:8]1[CH2:31][CH2:30][C:11]2([C:15](=[O:16])[N:14]([C:17]3[CH:22]=[CH:21][C:20]([O:23][CH:24]([CH3:29])[C:25]([F:28])([F:27])[F:26])=[CH:19][CH:18]=3)[CH2:13][CH2:12]2)[CH:10]([OH:32])[CH2:9]1)C1C=CC=CC=1>[OH-].[OH-].[Pd+2]>[OH:32][CH:10]1[CH2:9][NH:8][CH2:31][CH2:30][C:11]21[C:15](=[O:16])[N:14]([C:17]1[CH:22]=[CH:21][C:20]([O:23][CH:24]([CH3:29])[C:25]([F:28])([F:26])[F:27])=[CH:19][CH:18]=1)[CH2:13][CH2:12]2

Participants

3

Reactant 1

HCID 58056626(5 SR,6RS)-8-benzyl-6-hydroxy-2-[4-((rac)-2,2,2-trifluoro-1-methyl-ethoxy)-phenyl]-2,8-diaza-spiro[4.5]decan-1-one

Product 1

HCID 58056627HCID 58056627, compound

Reagents, catalysts & solvents 1

HCID 9942167Palladium hydroxideCatalyst

Procedure

The title compound was prepared in analogy to example 2 step A from a mixture of (5 SR,6RS)-8-benzyl-6-hydroxy-2-[4-((rac)-2,2,2-trifluoro-1-methyl-ethoxy)-phenyl]-2,8-diaza-spiro[4.5]decan-1-one and Pearlman's catalyst under an atmosphere of hydrogen. Light brown solid. MS (ESI): 359.1 (MH+)

Sources & evidence

ORD record
ord-9d341dbe0ee64a889de9ad170a79e26f
Source dataset
uspto-grants-2013_06
Patent number
US08470843B2

Reaction notes

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