反应详情

温度

0 °C

Diisobutylaluminum hydride (7.08 ml) was slowly added dropwise to dimethyl 2-(4-benzyloxyphenoxy)malonate (477 mg, 1.44 mmol) in 16 ml of toluene under argon at 0° C. The reaction mixture was stirred at 0° C. for 2 h and, after addition of 1M hydrochloric acid solution, extracted with ethyl acetate. The organic phase was separated off, concentrated and purified by preparative HPLC (PR18, acetonitrile/water 0.1% TFA). Yield: 98.6 mg (25%), M+H+: 275.20.

1. extractionextracted with ethyl acetate
2. customThe organic phase was separated off
3. concentrationconcentrated
4. custompurified by preparative HPLC (PR18, acetonitrile/water 0.1% TFA)