HCID 178474770, compound → HCID 178474769, compound

HRID 1260507Notes

Reaction equation

HRID 1260507 reaction equation
C([O:8][C:9]1[CH:28]=[CH:27][C:12]([O:13][C@H:14]2[CH2:19][O:18][C@@H:17]([CH2:20][CH2:21][CH2:22][NH:23][C:24](=[O:26])[CH3:25])[O:16][CH2:15]2)=[CH:11][CH:10]=1)C1C=CC=CC=1>C(O)C.[Pd]>[OH:8][C:9]1[CH:10]=[CH:11][C:12]([O:13][C@H:14]2[CH2:15][O:16][C@@H:17]([CH2:20][CH2:21][CH2:22][NH:23][C:24](=[O:26])[CH3:25])[O:18][CH2:19]2)=[CH:27][CH:28]=1

Participants

4

Reactant 1

HCID 178474770HCID 178474770, compound

Product 1

HCID 178474769HCID 178474769, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

cis-N-{3-[5-(4-Benzyloxyphenoxy)-[1,3]dioxan-2-yl]propyl}acetamide (25 mg, 0.065 mmol) was dissolved in 5 ml of ethanol and hydrogenated in the presence of 0.69 mg of palladium/carbon under 3 bar for 1 h. The reaction mixture was concentrated and directly reacted further. Yield 18 mg.

Workup

  1. concentrationThe reaction mixture was concentrated
  2. customdirectly reacted further

Sources & evidence

ORD record
ord-725d179ca8a04b649fc752bc0661d607
Source dataset
uspto-grants-2013_06
Patent number
US08470841B2

Reaction notes

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