反应详情

N-{3-[4-(5-Hydroxypyridin-2-yloxy)phenyl]-1-methylpropyl}acetamide (50 mg, 166 μmol), 2-iodopropane (28 mg, 166 μmol) and cesium carbonate (135 mg, 416 μmol) were stirred in 3 ml of DMF at 50° C. for 3 h. The reaction mixture was concentrated in vacuo, and the residue was purified by preparative HPLC (PR18, acetonitrile/water 0.1% TFA). Yield: 35 mg (61%), M+H+: 343.16.

1. concentrationThe reaction mixture was concentrated in vacuo
2. customthe residue was purified by preparative HPLC (PR18, acetonitrile/water 0.1% TFA)