Hydrochloric Acid → HCID 49855595, compound

HRID 1260519Notes

Reaction equation

HRID 1260519 reaction equation
[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][C:12]([O:15][CH:16]2[CH2:21][O:20]C(C3C=CC=CC=3)[O:18][CH2:17]2)=[N:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl>CO>[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][C:12]([O:15][CH:16]([CH2:17][OH:18])[CH2:21][OH:20])=[N:13][CH:14]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 49857899HCID 49857899, compound

Product 1

HCID 49855595HCID 49855595, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

5-Benzyloxy-2-(2-phenyl-[1,3]dioxan-5-yloxy)pyridine was mixed with 20 ml of 4N hydrochloric acid and 20 ml of methanol and stirred at RT for 2 h. The methanol was concentrated in vacuo and the resulting acidic solution was made alkaline with saturated sodium carbonate solution. The alkaline solution was extracted with ethyl acetate, and the organic phase was concentrated.

Workup

  1. concentrationThe methanol was concentrated in vacuo
  2. extractionThe alkaline solution was extracted with ethyl acetate
  3. concentrationthe organic phase was concentrated

Sources & evidence

ORD record
ord-acabf1142b464e1f9375555a2aa54237
Source dataset
uspto-grants-2013_06
Patent number
US08470841B2

Reaction notes

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