5-Bromo-2-chloropyrimidine → HCID 86656065, compound

HRID 1260522Notes

Reaction equation

HRID 1260522 reaction equation
[Cl:1][C:2]1[N:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.[Br:9][C:10]1[CH:11]=[N:12][C:13](Cl)=[N:14][CH:15]=1>>[Br:9][C:10]1[CH:11]=[N:12][C:13]([O:8][C:5]2[CH:6]=[N:7][C:2]([Cl:1])=[CH:3][CH:4]=2)=[N:14][CH:15]=1

Participants

3

Reactant 2

HCID 6066655-Bromo-2-chloropyrimidineHCID 8198212-Chloro-5-hydroxypyridine

Product 1

HCID 86656065HCID 86656065, compound

Procedure

6-Chloropyridin-3-ol (670 mg, 5.17 mmol) and 5-bromo-2-chloropyrimidine (1.0 g, 5.17 mmol) were reacted in analogy to example 2c. Yield: 1.02 g (69%), M+H+: 285.95.

Sources & evidence

ORD record
ord-eaab43ec051f47d68987a2f0f9429dbe
Source dataset
uspto-grants-2013_06
Patent number
US08470841B2

Reaction notes

Loading…