反应详情

2-{3-[4-(6-Benzyloxypyridin-3-yloxy)phenyl]-1-methylprop-2-ynyl}isoindole-1,3-dione (2.0 g, 2.32 mmol) and hydrazine hydrate (0.57 ml, 11.82 mmol) were stirred in 40 ml of ethanol at 100° C. for 2 h. The reaction mixture was concentrated, heated with ethyl acetate and filtered hot. The filtrate was concentrated. Yield: 800 mg (100%), M+H+: 345.15.

1. concentrationThe reaction mixture was concentrated
2. temperatureheated with ethyl acetate
3. filtrationfiltered hot
4. concentrationThe filtrate was concentrated