2-Bromopropane → N-{(S)-2-[6-(4-Isopropoxyphenoxy)pyridin-3-yloxy]-1-methylethyl}acetamide

HRID 1260547Notes

Reaction equation

HRID 1260547 reaction equation
[OH:1][C:2]1[CH:22]=[CH:21][C:5]([O:6][C:7]2[N:12]=[CH:11][C:10]([O:13][CH2:14][C@@H:15]([NH:17][C:18](=[O:20])[CH3:19])[CH3:16])=[CH:9][CH:8]=2)=[CH:4][CH:3]=1.Br[CH:24]([CH3:26])[CH3:25]>>[CH:24]([O:1][C:2]1[CH:3]=[CH:4][C:5]([O:6][C:7]2[N:12]=[CH:11][C:10]([O:13][CH2:14][C@@H:15]([NH:17][C:18](=[O:20])[CH3:19])[CH3:16])=[CH:9][CH:8]=2)=[CH:21][CH:22]=1)([CH3:26])[CH3:25]

Participants

3

Reactant 2

HCID 63582-BromopropaneHCID 67071771N-{(S)-2-[6-(4-Hydroxyphenoxy)pyridin-3-yloxy]-1-methylethyl}acetamide

Product 1

HCID 58369058N-{(S)-2-[6-(4-Isopropoxyphenoxy)pyridin-3-yloxy]-1-methylethyl}acetamide

Procedure

N—{(S)-2-[6-(4-Hydroxyphenoxy)pyridin-3-yloxy]-1-methylethyl}acetamide (33 mg, 0.1 mmol) and 2-bromopropane (16 mg, 0.13 mmol) were reacted in analogy to example 1a. Yield: 23 mg (62%), M+H+: 345.19.

Sources & evidence

ORD record
ord-c2ecc5a053df462ca7e727addaaa64cd
Source dataset
uspto-grants-2013_06
Patent number
US08470841B2

Reaction notes

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