1,1'-Carbonyldiimidazole → HCID 49855399, compound

HRID 1260552Notes

Reaction equation

HRID 1260552 reaction equation
FC(F)(F)[C:3](O)=[O:4].[CH:8]([O:11][C:12]1[N:17]=[CH:16][C:15]([O:18][C:19]2[CH:24]=[CH:23][C:22]([CH2:25][CH2:26][CH:27]([NH2:29])[CH3:28])=[CH:21][CH:20]=2)=[CH:14][CH:13]=1)([CH3:10])[CH3:9].C(N1C=CN=C1)(N1C=CN=C1)=O>C(O)=O>[CH:8]([O:11][C:12]1[N:17]=[CH:16][C:15]([O:18][C:19]2[CH:20]=[CH:21][C:22]([CH2:25][CH2:26][CH:27]([NH:29][CH:3]=[O:4])[CH3:28])=[CH:23][CH:24]=2)=[CH:14][CH:13]=1)([CH3:10])[CH3:9]

Participants

4

Reactant 2

HCID 682631,1'-CarbonyldiimidazoleHCID 67071742HCID 67071742, compound

Product 1

HCID 49855399HCID 49855399, compound

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

3-[4-(6-Isopropoxypyridin-3-yloxy)phenyl]-1-methylpropylamine trifluoroacetate (115 mg, 0.28 mmol) was reacted with formic acid and 1,1′-carbonyldiimidazole in analogy to example 44. Yield: 46 mg (51%), M+H+: 329.18.

Sources & evidence

ORD record
ord-91c715750aec42ab815433ce2de7f186
Source dataset
uspto-grants-2013_06
Patent number
US08470841B2

Reaction notes

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