1,1'-Carbonyldiimidazole → HCID 49855402, compound

HRID 1260554Notes

Reaction equation

HRID 1260554 reaction equation
[CH:1]([O:4][C:5]1[N:10]=[CH:9][C:8]([O:11][C:12]2[CH:17]=[CH:16][C:15]([CH2:18][CH2:19][CH:20]([NH2:22])[CH3:21])=[CH:14][CH:13]=2)=[CH:7][CH:6]=1)([CH3:3])[CH3:2].[C:23](N1C=CN=C1)([N:25]1C=CN=C1)=[O:24]>C(O)=O>[CH:1]([O:4][C:5]1[N:10]=[CH:9][C:8]([O:11][C:12]2[CH:13]=[CH:14][C:15]([CH2:18][CH2:19][CH:20]([NH:22][C:23]([NH2:25])=[O:24])[CH3:21])=[CH:16][CH:17]=2)=[CH:7][CH:6]=1)([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 682631,1'-CarbonyldiimidazoleHCID 67071743HCID 67071743, compound

Product 1

HCID 49855402HCID 49855402, compound

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

3-[4-(6-Isopropoxypyridin-3-yloxy)phenyl]-1-methylpropylamine (115 mg, 0.38 mmol) was reacted with formic acid and 1,1′-carbonyldiimidazole in analogy to example 44. Yield: 5 mg (4%), M+H+: 344.19.

Sources & evidence

ORD record
ord-0cdc841937e7469194399027380682f1
Source dataset
uspto-grants-2013_06
Patent number
US08470841B2

Reaction notes

Loading…