Pyridine → HCID 86656071, compound

HRID 1260561Notes

Reaction equation

HRID 1260561 reaction equation
[CH:1]([O:4][C:5]1[N:10]=[CH:9][C:8]([O:11][C:12]2[CH:17]=[CH:16][C:15]([CH2:18][CH2:19][C:20](=O)[CH:21]([CH3:23])[CH3:22])=[CH:14][CH:13]=2)=[CH:7][CH:6]=1)([CH3:3])[CH3:2].Cl.[CH2:26]([O:33][NH2:34])[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1.N1C=CC=CC=1>C(O)C>[CH2:26]([O:33][N:34]=[C:20]([CH:21]([CH3:23])[CH3:22])[CH2:19][CH2:18][C:15]1[CH:16]=[CH:17][C:12]([O:11][C:8]2[CH:9]=[N:10][C:5]([O:4][CH:1]([CH3:3])[CH3:2])=[CH:6][CH:7]=2)=[CH:13][CH:14]=1)[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1

Participants

5

Reactant 3

HCID 1049PyridineHCID 102312Benzyloxyamine hydrochlorideHCID 67302610HCID 67302610, compound

Product 1

HCID 86656071HCID 86656071, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1-[4-(6-Isopropoxypyridin-3-yloxy)phenyl]-4-methylpentan-3-one (310 mg, 0.947 mmol) was stirred with O-benzylhydroxylamine hydrochloride (181 mg, 1.14 mmol) and pyridine (0.92 ml, 1.14 mmol) in 5 ml of ethanol at room temperature for 18 h. The reaction mixture was concentrated and further reacted without purification. Yield: 310 mg, M+H+: 433.26.

Workup

  1. concentrationThe reaction mixture was concentrated
  2. customfurther reacted without purification

Sources & evidence

ORD record
ord-3925882072e3471a800518980c27e7ec
Source dataset
uspto-grants-2013_06
Patent number
US08470841B2

Reaction notes

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