(E)-4-(4-Hydroxyphenyl)-3-buten-2-one → HCID 67071785, compound

HRID 1260565Notes

Reaction equation

HRID 1260565 reaction equation
[CH:1]([O:4][C:5]1[CH:10]=[CH:9][C:8](B2OC(C)(C)C(C)(C)O2)=[CH:7][N:6]=1)([CH3:3])[CH3:2].[OH:20][C:21]1[CH:26]=[CH:25][C:24](/[CH:27]=[CH:28]/[C:29](=[O:31])[CH3:30])=[CH:23][CH:22]=1>>[CH:1]([O:4][C:5]1[N:6]=[CH:7][C:8]([O:20][C:21]2[CH:22]=[CH:23][C:24](/[CH:27]=[CH:28]/[C:29](=[O:31])[CH3:30])=[CH:25][CH:26]=2)=[CH:9][CH:10]=1)([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 796857(E)-4-(4-Hydroxyphenyl)-3-buten-2-oneHCID 242087982-Isopropoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

Product 1

HCID 67071785HCID 67071785, compound

Procedure

2-Isopropoxy-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)pyridine (3.24 g, 12.33 mmol) and (E)-4-(4-hydroxyphenyl)but-3-en-2-one (2.0 g, 12.33 mmol) were reacted in analogy to example 50a. Yield: 304 mg (8%), M+H+: 298.2.

Sources & evidence

ORD record
ord-3947fff1a8f34076a2942a08e8bab04c
Source dataset
uspto-grants-2013_06
Patent number
US08470841B2

Reaction notes

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