4-Fluoro-2-(trifluoromethyl)benzaldehyde → 2-(Bromomethyl)-5-(methylsulphonyl)benzotrifluoride

HRID 1260643Notes

Reaction equation

HRID 1260643 reaction equation
[Br:1][CH2:2][C:3]1[CH:8]=[CH:7][C:6]([S:9]([CH3:12])(=[O:11])=[O:10])=[CH:5][C:4]=1Cl.FC1C=CC(C=O)=C([C:23]([F:26])([F:25])[F:24])C=1>>[Br:1][CH2:2][C:3]1[CH:8]=[CH:7][C:6]([S:9]([CH3:12])(=[O:11])=[O:10])=[CH:5][C:4]=1[C:23]([F:26])([F:25])[F:24]

Participants

3

Reactant 2

HCID 5229404-Fluoro-2-(trifluoromethyl)benzaldehydeHCID 27610831-(Bromomethyl)-2-chloro-4-(methylsulfonyl)benzene

Product 1

HCID 513420492-(Bromomethyl)-5-(methylsulphonyl)benzotrifluoride

Procedure

The titled compound is prepared analogously to 1-bromomethyl-2-chloro-4-methanesulfonyl-benzene by replacing 2-chloro-4-fluorobenzaldehyde (step 90a) with 4-fluoro-2-trifluoromethylbenzaldehyde.

Sources & evidence

ORD record
ord-01caf164b4df4a1883ba3a48cc5aca67
Source dataset
uspto-grants-2013_06
Patent number
US08470848B2

Reaction notes

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