反应详情

温度

60 °C

A 2M aq. LiOH sol. (125 ml) was added to a solution of 15.0 g (50.1 mmol) 2-hydroxy-4-methyl-7-(trifluoromethyl)quinoline-3-carboxylic acid ethyl ester in a MeOH/THF mixture (in each case 175 ml) and the mixture was subsequently heated to 60° C. for 16 h. The mixture was subsequently concentrated in a vacuum. The residue was taken up with water and adjusted to pH 2 with a 2M hydrochloric acid. Extraction was then carried out with EtOAc. The organic phase was washed with brine, dried over MgSO4 and concentrated in a vacuum. 12.0 g (44.2 mmol, 88%) 2-hydroxy-4-methyl-7-(trifluoromethyl)quinoline-3-carboxylic acid was obtained as a residue. The raw product was further converted without additional purification.

1. concentrationThe mixture was subsequently concentrated in a vacuum
2. extractionExtraction
3. washThe organic phase was washed with brine
4. dry with materialdried over MgSO4
5. concentrationconcentrated in a vacuum