3,3,3-Trifluoropropionic acid → HCID 178520719, compound

HRID 1260735Notes

Reaction equation

HRID 1260735 reaction equation
Cl.Cl.Cl.[O:4]1[C:8]2=[C:9]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C@H:21]4[CH2:26][CH2:25][C@H:24]([NH2:27])[CH2:23][CH2:22]4)[CH2:15][CH2:14]3)[N:10]=[CH:11][CH:12]=[C:7]2[CH2:6][CH2:5]1.[F:28][C:29]([F:35])([F:34])[CH2:30][C:31](O)=[O:32]>>[O:4]1[C:8]2=[C:9]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C@H:21]4[CH2:26][CH2:25][C@H:24]([NH:27][C:31](=[O:32])[CH2:30][C:29]([F:35])([F:34])[F:28])[CH2:23][CH2:22]4)[CH2:15][CH2:14]3)[N:10]=[CH:11][CH:12]=[C:7]2[CH2:6][CH2:5]1

Participants

3

Reactant 2

HCID 27779723,3,3-Trifluoropropionic acidHCID 178478590HCID 178478590, compound2×

Product 1

HCID 178520719HCID 178520719, compound

Procedure

The title compound, white solid (49 mg, 70%), MS (ISP) m/z=441.4 [(M+H)+], mp 216.5° C., was prepared in accordance with the general method of example 6 from trans-4-{2-[4-(2,3-dihydro-furo[2,3-c]pyridin-7-yl)-piperazin-1-yl]-ethyl}-cyclohexylamine trihydrochloride (intermediate B) (70.4 mg, 0.16 mmol) 3,3,3-trifluoropropanoic acid.

Sources & evidence

ORD record
ord-4220f30c342a4e0c8056f600f07c2e67
Source dataset
uspto-grants-2013_06
Patent number
US08470828B2

Reaction notes

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