HCID 2779071, compound → HCID 178520778, compound

HRID 1260748Notes

Reaction equation

HRID 1260748 reaction equation
Cl.Cl.Cl.[O:4]1[C:8]2=[C:9]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C@H:21]4[CH2:26][CH2:25][C@H:24]([NH2:27])[CH2:23][CH2:22]4)[CH2:15][CH2:14]3)[N:10]=[CH:11][CH:12]=[C:7]2[CH2:6][CH2:5]1.[F:28][C:29]([F:37])([F:36])[C@H:30]([OH:35])[CH2:31][C:32](O)=[O:33]>>[O:4]1[C:8]2=[C:9]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C@H:21]4[CH2:26][CH2:25][C@H:24]([NH:27][C:32](=[O:33])[CH2:31][C@@H:30]([OH:35])[C:29]([F:37])([F:36])[F:28])[CH2:23][CH2:22]4)[CH2:15][CH2:14]3)[N:10]=[CH:11][CH:12]=[C:7]2[CH2:6][CH2:5]1

Participants

3

Reactant 2

HCID 2779071HCID 2779071, compoundHCID 178478590HCID 178478590, compound2×

Product 1

HCID 178520778HCID 178520778, compound

Procedure

The title compound, white solid (133 mg, 94%), MS (ISP) m/z=471.5 [(M+H)+], mp 214.5° C., was prepared in accordance with the general method of example 6 from trans-4-{2-[4-(2,3-dihydro-furo[2,3-c]pyridin-7-yl)-piperazin-1-yl]-ethyl}-cyclohexylamine trihydrochloride (intermediate B) (110 mg, 0.25 mmol) and (R)-4,4,4-trifluoro-3-hydroxybutanoic acid.

Sources & evidence

ORD record
ord-c3a5c365b5644561b57b1245a139b303
Source dataset
uspto-grants-2013_06
Patent number
US08470828B2

Reaction notes

Loading…