4-(Trifluoromethyl)benzoic acid → HCID 178523726, compound

HRID 1260755Notes

Reaction equation

HRID 1260755 reaction equation
Cl.Cl.Cl.[O:4]1[C:8]2=[C:9]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C@H:21]4[CH2:26][CH2:25][C@H:24]([NH2:27])[CH2:23][CH2:22]4)[CH2:15][CH2:14]3)[N:10]=[CH:11][CH:12]=[C:7]2[CH2:6][CH2:5]1.[F:28][C:29]([F:40])([F:39])[C:30]1[CH:38]=[CH:37][C:33]([C:34](O)=[O:35])=[CH:32][CH:31]=1>>[O:4]1[C:8]2=[C:9]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C@H:21]4[CH2:26][CH2:25][C@H:24]([NH:27][C:34](=[O:35])[C:33]5[CH:37]=[CH:38][C:30]([C:29]([F:28])([F:39])[F:40])=[CH:31][CH:32]=5)[CH2:23][CH2:22]4)[CH2:15][CH2:14]3)[N:10]=[CH:11][CH:12]=[C:7]2[CH2:6][CH2:5]1

Participants

3

Reactant 2

HCID 99664-(Trifluoromethyl)benzoic acidHCID 178478590HCID 178478590, compound2×

Product 1

HCID 178523726HCID 178523726, compound

Procedure

The title compound, white solid (117 mg, 93%), MS (ISP) m/z=503.3 [(M+H)+], mp 242.5° C., was prepared in accordance with the general method of example 6 from trans-4-{2-[4-(2,3-dihydro-furo[2,3-c]pyridin-7-yl)-piperazin-1-yl]-ethyl}-cyclohexylamine trihydrochloride (intermediate B) (110 mg, 0.25 mmol) and 4-trifluoromethyl-benzoic acid.

Sources & evidence

ORD record
ord-77ea2b7456f94f18a828e7599f931382
Source dataset
uspto-grants-2013_06
Patent number
US08470828B2

Reaction notes

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