2-Hydroxyisobutyric acid → HCID 178459882, compound

HRID 1260759Notes

Reaction equation

HRID 1260759 reaction equation
Cl.Cl.Cl.[O:4]1[C:8]2=[C:9]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C@H:21]4[CH2:26][CH2:25][C@H:24]([NH2:27])[CH2:23][CH2:22]4)[CH2:15][CH2:14]3)[N:10]=[CH:11][CH:12]=[C:7]2[CH2:6][CH2:5]1.[OH:28][C:29]([CH3:34])([CH3:33])[C:30](O)=[O:31]>>[O:4]1[C:8]2=[C:9]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C@H:21]4[CH2:26][CH2:25][C@H:24]([NH:27][C:30](=[O:31])[C:29]([OH:28])([CH3:34])[CH3:33])[CH2:23][CH2:22]4)[CH2:15][CH2:14]3)[N:10]=[CH:11][CH:12]=[C:7]2[CH2:6][CH2:5]1

Participants

3

Reactant 2

HCID 116712-Hydroxyisobutyric acidHCID 178478590HCID 178478590, compound2×

Product 1

HCID 178459882HCID 178459882, compound

Procedure

The title compound, white solid (92 mg, 88%), MS (ISP) m/z=417.5 [(M+H)+], mp 241° C., was prepared in accordance with the general method of example 6 from trans-4-{2-[4-(2,3-dihydro-furo[2,3-c]pyridin-7-yl)-piperazin-1-yl]-ethyl}-cyclohexylamine trihydrochloride (intermediate B) (110 mg, 0.25 mmol) and 2-hydroxy-2-methyl-propionic acid.

Sources & evidence

ORD record
ord-9a03513052db40658c567f5754261709
Source dataset
uspto-grants-2013_06
Patent number
US08470828B2

Reaction notes

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