3-Methylisoxazole-5-carboxylic acid → HCID 178427119, compound

HRID 1260761Notes

Reaction equation

HRID 1260761 reaction equation
Cl.Cl.Cl.[O:4]1[C:8]2=[C:9]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C@H:21]4[CH2:26][CH2:25][C@H:24]([NH2:27])[CH2:23][CH2:22]4)[CH2:15][CH2:14]3)[N:10]=[CH:11][CH:12]=[C:7]2[CH2:6][CH2:5]1.[CH3:28][C:29]1[CH:33]=[C:32]([C:34](O)=[O:35])[O:31][N:30]=1>>[O:4]1[C:8]2=[C:9]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C@H:21]4[CH2:26][CH2:25][C@H:24]([NH:27][C:34]([C:32]5[O:31][N:30]=[C:29]([CH3:28])[CH:33]=5)=[O:35])[CH2:23][CH2:22]4)[CH2:15][CH2:14]3)[N:10]=[CH:11][CH:12]=[C:7]2[CH2:6][CH2:5]1

Participants

3

Reactant 2

HCID 8530853-Methylisoxazole-5-carboxylic acidHCID 178478590HCID 178478590, compound2×

Product 1

HCID 178427119HCID 178427119, compound

Procedure

The title compound, white solid (99 mg, 90%), MS (ISP) m/z=440.4 [(M+H)+], mp 199° C., was prepared in accordance with the general method of example 6 from trans-4-{2-[4-(2,3-dihydro-furo[2,3-c]pyridin-7-yl)-piperazin-1-yl]-ethyl}-cyclohexylamine trihydrochloride (intermediate B) (110 mg, 0.25 mmol) and 3-methyl-isoxazole-5-carboxylic acid.

Sources & evidence

ORD record
ord-6b3922d101d0423f912b56b436b48966
Source dataset
uspto-grants-2013_06
Patent number
US08470828B2

Reaction notes

Loading…