2,4-Dichlorobenzoic Acid → HCID 178523728, compound

HRID 1260767Notes

Reaction equation

HRID 1260767 reaction equation
Cl.Cl.Cl.[O:4]1[C:8]2=[C:9]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C@H:21]4[CH2:26][CH2:25][C@H:24]([NH2:27])[CH2:23][CH2:22]4)[CH2:15][CH2:14]3)[N:10]=[CH:11][CH:12]=[C:7]2[CH2:6][CH2:5]1.[Cl:28][C:29]1[CH:37]=[C:36]([Cl:38])[CH:35]=[CH:34][C:30]=1[C:31](O)=[O:32]>>[Cl:28][C:29]1[CH:37]=[C:36]([Cl:38])[CH:35]=[CH:34][C:30]=1[C:31]([NH:27][C@H:24]1[CH2:25][CH2:26][C@H:21]([CH2:20][CH2:19][N:16]2[CH2:17][CH2:18][N:13]([C:9]3[N:10]=[CH:11][CH:12]=[C:7]4[CH2:6][CH2:5][O:4][C:8]=34)[CH2:14][CH2:15]2)[CH2:22][CH2:23]1)=[O:32]

Participants

3

Reactant 2

HCID 57872,4-Dichlorobenzoic AcidHCID 178478590HCID 178478590, compound2×

Product 1

HCID 178523728HCID 178523728, compound

Procedure

The title compound, white solid (119 mg, 95%), MS (ISP) m/z=503.2 [(M+H)+], mp 243.5° C., was prepared in accordance with the general method of example 6 from trans-4-{2-[4-(2,3-dihydro-furo[2,3-c]pyridin-7-yl)-piperazin-1-yl]-ethyl}-cyclohexylamine trihydrochloride (intermediate B) (110 mg, 0.25 mmol) and 2,4-dichloro-benzoic acid.

Sources & evidence

ORD record
ord-bd2e559e51854a4398c3f3fe53a2d080
Source dataset
uspto-grants-2013_06
Patent number
US08470828B2

Reaction notes

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