(1,1'-Biphenyl)-4-carboxylic acid → HCID 178523723, compound

HRID 1260770Notes

Reaction equation

HRID 1260770 reaction equation
Cl.Cl.Cl.[O:4]1[C:8]2=[C:9]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C@H:21]4[CH2:26][CH2:25][C@H:24]([NH2:27])[CH2:23][CH2:22]4)[CH2:15][CH2:14]3)[N:10]=[CH:11][CH:12]=[C:7]2[CH2:6][CH2:5]1.[C:28]1([C:37]2[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=2)[CH:33]=[CH:32][C:31]([C:34](O)=[O:35])=[CH:30][CH:29]=1>>[O:4]1[C:8]2=[C:9]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C@H:21]4[CH2:26][CH2:25][C@H:24]([NH:27][C:34]([C:31]5[CH:32]=[CH:33][C:28]([C:37]6[CH:38]=[CH:39][CH:40]=[CH:41][CH:42]=6)=[CH:29][CH:30]=5)=[O:35])[CH2:23][CH2:22]4)[CH2:15][CH2:14]3)[N:10]=[CH:11][CH:12]=[C:7]2[CH2:6][CH2:5]1

Participants

3

Reactant 2

HCID 66724(1,1'-Biphenyl)-4-carboxylic acidHCID 178478590HCID 178478590, compound2×

Product 1

HCID 178523723HCID 178523723, compound

Procedure

The title compound, white solid (117 mg, 92%), MS (ISP) m/z=511.6 [(M+H)+], mp 220.5° C., was prepared in accordance with the general method of example 6 from trans-4-{2-[4-(2,3-dihydro-furo[2,3-c]pyridin-7-yl)-piperazin-1-yl]-ethyl}-cyclohexylamine trihydrochloride (intermediate B) (110 mg, 0.25 mmol) and biphenyl-4-carboxylic acid.

Sources & evidence

ORD record
ord-360b6eb8cfd64bae9fdf515d3ca08003
Source dataset
uspto-grants-2013_06
Patent number
US08470828B2

Reaction notes

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