1-Hydroxycyclobutanecarboxylic acid → HCID 178523742, compound

HRID 1260779Notes

Reaction equation

HRID 1260779 reaction equation
Cl.Cl.Cl.[O:4]1[C:8]2=[C:9]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C@H:21]4[CH2:26][CH2:25][C@H:24]([NH2:27])[CH2:23][CH2:22]4)[CH2:15][CH2:14]3)[N:10]=[CH:11][CH:12]=[C:7]2[CH2:6][CH2:5]1.[OH:28][C:29]1([C:33](O)=[O:34])[CH2:32][CH2:31][CH2:30]1>>[O:4]1[C:8]2=[C:9]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C@H:21]4[CH2:26][CH2:25][C@H:24]([NH:27][C:33]([C:29]5([OH:28])[CH2:32][CH2:31][CH2:30]5)=[O:34])[CH2:23][CH2:22]4)[CH2:15][CH2:14]3)[N:10]=[CH:11][CH:12]=[C:7]2[CH2:6][CH2:5]1

Participants

3

Reactant 2

HCID 109534701-Hydroxycyclobutanecarboxylic acidHCID 178478590HCID 178478590, compound2×

Product 1

HCID 178523742HCID 178523742, compound

Procedure

The title compound, off-white solid (68 mg, 64%), MS (ISP) m/z=429.4 [(M+H)+], mp 250° C., was prepared in accordance with the general method of example 6 from trans-4-{2-[4-(2,3-dihydro-furo[2,3-c]pyridin-7-yl)-piperazin-1-yl]-ethyl}-cyclohexylamine trihydrochloride (intermediate B) (110 mg, 0.25 mmol) and 1-hydroxy-cyclobutane-carboxylic acid.

Sources & evidence

ORD record
ord-1e96b92c7ea24a6295829dd0c26178a0
Source dataset
uspto-grants-2013_06
Patent number
US08470828B2

Reaction notes

Loading…